ISBN : 9780128244647
Author : Oliana Carnevali
Publisher : Academic Press
Year : 2023
Language : English
Type : Book
Description : Table of contents Cover image Title page Table of Contents Copyright Dedication Contributors Foreword Preface Acknowledgments Chapter 1: Endocrine-disrupting chemical sources and effects Chapter 1.1: Endocrine system Abstract 1: Fundamentals of hormones 2: Vertebrate endocrine physiology: Organs, axes, and hormones References Further reading Chapter 1.2: Endocrine-disrupting chemicals (EDCs) in environmental matrices and human bodily fluids Abstract 1: Introduction 2: Endocrine-disrupting chemicals (EDCs) 3: EDCs sources, exposure and presence in tissues and body fluids 4: Plastics 5: Pesticides 6: Flame retardants 7: Poly- and perfluoroalkyl substances (PFASs) 8: Polychlorinated biphenyls (PCBs) 9: Sunscreen 10: Conclusion References Chapter 1.3: In vitro-, ecological-, murine, and human models for examining the effects of EDCs Abstract 1: Summary 2: In vitro models for examining the effects of EDCs 3: Ecological models for examining the effects of EDCs 4: Murine models for examining the effects of EDCs 5: Human models for examining the effects of EDCs 6: Overview References Chapter 1.4: Endocrine-disrupting chemicals and their mode of action: The case of nuclear receptors and the evolution of the Metazoa Abstract 1: Introduction 2: Evolution and nuclear receptors: A conceptual framework 3: Endocrine disruption via nuclear receptors 4: Conclusions References Chapter 1.5: EDCs impacts on human populations. Addressing multiple chemicals in human exposure and epidemiological studies Abstract 1: Background 2: Assessing chemical mixtures in a birth cohort study: A simulated example 3: Conclusions References Chapter 2: Endocrine-disrupting chemicals as source of disease and health impairment in laboratory models Chapter 2.1: EDCs: Focus on metabolic alteration of mammalian and nonmammalian models Abstract 1: Introduction 2: Approaches used to investigate the adverse actions of EDCs on the liver function 3: Hepatic metabolism alteration in nonmammalian model species: A 5-year survey 4: Hepatic metabolism alteration in mammalian species: A 5-year survey 5: Conclusions References Chapter 2.2: EDCs: Focus on reproductive alterations in mammalian and nonmammalian models Abstract 1: Introduction 2: Reproductive toxicity outcomes in nonmammalian and mammalian species: A 5-year survey 3: Are microplastics deleterious for reproduction in mammals? 4: Conclusion References Chapter 2.3: The EDCs as epigenetic disruptors: Implications for development and health Abstract 1: Introduction to epigenetics 2: Interference of EDCs with the epigenetic dynamics 3: The impact of epigenetic effects triggered by EDCs on health conditions 4: Concluding remarks References Chapter 2.4: Endocrine disrupting chemicals induce the epigenetic transgenerational inheritance of disease Abstract Acknowledgments 1: Introduction 2: Molecular epigenetic mechanisms 3: Epigenetic transgenerational inheritance 4: Developmental etiology of epigenetic transgenerational inheritance 5: Germline epimutations 6: Transgenerational gene expression changes 7: Conclusion References Chapter 2.5: Endocrine disruption persistence through development and across generations can be mediated by environmental perturbations of the heterochromatin/euchromatin compartmentalization Abstract 1: Introduction 2: Environmental perturbation of genome organization as DIPE mediator 3: How do HEC perturbations determine the phenotypic manifestations of DIPE? 4: How are HEC perturbations propagated? 5: How are HEC perturbations originated? 6: Concluding remarks References Chapter 2.6: Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction Abstract 1: The endocannabinoid system 2: Endocannabinoid system, endocrine-disrupting chemicals, and hepatic metabolism 3: Endocannabinoid system, endocrine-disrupting chemicals, and reproduction 4: Conclusions References Chapter 3: Endocrine-disrupting chemicals; cause of disease and health impairment in human and wild species Chapter 3.1: EDC effects in humans Chapter 3.1.1: Metabolism disrupting chemicals in the development of human diseases Abstract Acknowledgments 1: Introduction 2: Common ground for MDC research 3: Organ and organ systems 4: MDC-related diseases 5: Type-II diabetes mellitus 6: Alzheimer's disease and “Type 3 diabetes” 7: Parkinson's disease 8: A slightly broader view of MDCs and the mitochondria 9: Expanding areas for MDC research 10: Looking backward and forward References Chapter 3.1.2: Focus on reproductive health and alterations in women Abstract 1: Introduction 2: Female reproductive health 3: EDCs and female reproductive health 4: Exposure in the womb 5: Effects on puberty 6: Polycystic ovary syndrome (PCOS) 7: Breast cancer 8: Endometriosis 9: Uterine fibroid (uterine leiomyoma) 10: Infertility 11: Pregnancy complications 12: Epigenetics and transgenerational effects 13: Conclusion and future perspectives References Chapter 3.1.3: EDCs: Focus on reproductive alterations in males Abstract 1: Introduction 2: Bisphenol A 3: Phthalates 4: Perfluoroalkyl substances 5: Dioxin and dioxin-like compounds 6: Conclusions References Chapter 3.1.4: A good start lasts a lifetime: Endocrine-disrupting chemicals and their impact on embryonic and fetal development Abstract 1: Introduction 2: Early embryonic development in the human 3: Measurements of early embryonic growth and development 4: Evidence that EDCs directly impact human early embryonic development 5: Late embryonic and fetal development in humans: A brief overview 6: Evaluating late embryonic and fetal development in humans 7: EDCs: Impact on organogenesis and fetal growth 8: Developmental origins of adult diseases 9: EDCs and the developmental origins of adult diseases 10: Conclusions References Chapter 3.1.5: Epidemiological studies on the effects of prenatal exposure to endocrine-disrupting compounds on fertility Abstract 1: Introduction 2: Male reproductive function 3: Discussion References Chapter 3.2: EDC effects in animals Chapter 3.2.1: Metabolism vs. metabolomics: Mechanisms of endocrine disruption Abstract 1: Metabolic transformations of chemical contaminants to active estrogenic targets 2: Metabolomics impacts of environmental contaminants References Chapter 3.2.2: Effects of EDCs on female reproductive system in reptiles Abstract 1: Introduction 2: Reptilian physiology 3: Reptilian reproductive strategy: Oviparous and viviparous 4: Parental nurturing behavior 5: Reptilian endocrine system 6: Endocrine disruption in wild reptile 7: Experimentally induced endocrine disruption in female reptile 8: Conclusions References Chapter 3.2.3: Effects of aquatic contaminants in female fish reproduction Abstract Acknowledgment 1: Neuroendocrine regulation of female fish reproduction 2: Example of contaminants affecting female fish reproduction References Chapter 3.2.4: EDCs: Focus on male fish reproductive alterations Abstract 1: Introduction 2: Male fish reproductive endocrinology 3: Environmental contaminants 4: Bisphenols 5: Metals 6: Pharmaceuticals 7: Insecticides 8: Alkylphenols References Chapter 3.2.5: Environmental endocrine-disrupting chemicals and their effects in marine mammals Abstract Acknowledgements 1: Introduction 2: Exposure to EDCs in marine mammals 3: Effects of EDCs in marine mammals 4: In vitro studies 5: Conclusion and future direction Appendix References Chapter 4: Removal of hazardous pollutants from wastewaters Chapter 4.1: Conventional wastewater treatment methods and their ability to remove EDCs Abstract Acknowledgments 1: Introduction 2: Characteristics of EDCs 3: Conventional wastewater treatment: A brief overview 4: Factors influencing the fate of EDCs 5: Conclusions References Chapter 4.2: Nanofiltration and ultrafiltration of endocrine-disrupting compounds Abstract 1: EDCs in aquatic environment 2: Removal of EDCs by membrane processes 3: Membrane materials for EDC removal 4: Removal mechanism of EDCs with UF membranes 5: Removal mechanism of EDCs with NF membranes 6: Rejection of EDCs by UF membrane systems 7: Rejection of EDCs by NF membrane systems References Chapter 4.3: Advanced oxidation processes for wastewater treatment Abstract 1: Introduction 2: Ozonation for EDCs degradation 3: UV photolysis and UV/H2O2 for EDCs degradation 4: Fenton and Fenton-like reaction 5: TiO2-catalyzed UV oxidation (UV/TiO2) 6: Conclusions References Chapter 4.4: Endocrine-disrupting compounds (EDCs) in conventional wastewater treatment: State of art and future challenges Abstract Acknowledgments 1: Conventional wastewater treatment plants as a source of EDCs 2: Research trends in EDCs removal in wastewater treatment plants 3: Final comments and future perspectives References Index