ISBN : 9780323999878
Author : Eman E. Taher
Publisher : Academic Press
Year : 2023
Language : English
Type : Book
Description : Table of contents Cover image Title page Table of Contents Copyright Dedication List of contributors About the editors Foreword Preface Epigraph Chapter 1. Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration Abstract 1.1 Cornea 1.2 Retina 1.3 Retinal ganglion cells and the optic nerve Conflict of interest References Chapter 2. Organoid-based modality of eye function and cellular processes Abstract Abbreviations Brief description of the eye structure 2.1 The need for innovative tools for eye biology, function, and diseases 2.2 Roles of the organoid culture in the cornea 2.3 Retina 2.4 Lacrimal glands 2.5 Lacrimal gland organoid cultures 2.6 Lens 2.7 Discussion and conclusion References Chapter 3. Leveraging neural crest pluripotency to extend retinal and craniofacial niches for building neurovascular organoids—a theranostic and drug development perspective Abstract 3.1 Introduction 3.2 Summary, conclusion, and future perspective Acknowledgments Disclaimer References Further reading Chapter 4. Role of stem cell engineering and or gene-editing technologies in eye diseases degeneration, and therapy Abstract 4.1 Introduction 4.2 Introducing stem cells 4.3 Induced pluripotent stem cell 4.4 Retina, retinal pigment epithelium 4.5 Examples of iPSCs implications in eye diseases 4.6 AMD 4.7 Photoreceptor cell disorders 4.8 RPE disorders 4.9 Eye disease and stem cell therapy 4.10 Gene therapy 4.11 Eye-related disorders 4.12 Conclusion References Chapter 5. Stem cells and genetic engineering empower therapeutic development for blinding eye diseases Abstract 5.1 Introduction 5.2 Stem cell therapy in eye diseases 5.3 Gene therapy in eye diseases 5.4 Conclusion Acknowledgements References Chapter 6. Human stem cell-derived retinal pigment epithelial cells for retinal regeneration: differentiation and clinical translation Abstract 6.1 Introduction 6.2 Differentiation of retinal pigment epithelium cells from human stem cells 6.3 Characteristics of HSC-RPE cells 6.4 Clinical translation of HSC-RPE cells 6.5 Discussion Acknowledgments References Further reading Chapter 7. Mesenchymal stem cells therapy for retinal diseases Abstract Abbreviations 7.1 Introduction 7.2 Challenges and prospects 7.3 Summary and conclusions References Chapter 8. Retinal cone photoreceptors from pluripotent stem cells for macular regeneration Abstract 8.1 Introduction 8.2 Mouse ESCs and PSCs-derived cone photoreceptors 8.3 Human ESCs and PSCs-derived cone photoreceptors 8.4 Transplantation of PSC-derived cone photoreceptors 8.5 Conclusions Acknowledgments References Chapter 9. Update on stem/progenitor cell-based clinical trials for eye disease Abstract 9.1 Retinal stem cell studies 9.2 Limbal stem cells studies References Chapter 10. Stem cell innovation in eye disease, repair and regeneration: general conclusion, challenges and prospective Abstract Abbreviations 10.1 Introduction 10.2 Roles of the organoids in modeling and investigating eye diseases 10.3 Roles of stem cells and genetic engineering technologies in empowering therapeutic development for blinding eye diseases 10.4 Application of stem cell types in eye diseases Conflicts of interest References Index