ISBN : 9780443158223
Author : Rossen Donev
Publisher : Academic Press
Year : 2023
Language : English
Type : Book
Description : Table of contents Cover Title page Table of Contents Copyright Contributors Chapter One: Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer Abstract 1: Introduction 2: Senescence-like cell cycle arrest in cancer 3: General signaling pathways engaged in senescence-like cell cycle arrest 4: Conclusion 5: Future perspective References Chapter Two: Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting Abstract 1: Introduction 2: Cyclins and cyclin-dependent kinases in cell cycle progression 3: Cyclin-dependent kinase inhibitors (CDKIs) in cancer therapeutics 4: Conclusion Ethical approval and consent to participate Consent for publication Availability of supporting data Competing interests References Chapter Three: Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase 4 protein Abstract 1: Introduction 2: Materials and methods 3: Results and discussion 4: Conclusion References Chapter Four: Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach Abstract 1: Introduction 2: Methodology 3: Results 4: Discussion 5: Conclusion References Chapter Five: CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells Abstract 1: Introduction 2: CDK regulators 3: Comparison between normal cells and cancerous cells 4: CDKI as therapeutics 5: Conclusion 6: Future prospects References Chapter Six: Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis Abstract 1: Introduction 2: Aberrant cell cycle checkpoints cooperate with cancer progression 3: AMBRA1 destabilizes cyclin D protein 4: Immunomodulatory function of cell cycle regulators 5: Cell cycle-based targeted cancer therapies 6: Targeting CK1ɛ for overcoming resistance to CDK4/6 inhibitors 7: Discussion Acknowledgment References Chapter Seven: The role of the nucleolus in regulating the cell cycle and the DNA damage response Abstract 1: Introduction 2: Nucleolus structure 3: The nucleolar proteome 4: Nucleolar assembly and disassembly during the cell cycle 5: The role of the nucleolus in regulating p53-dependent cell cycle events 6: p53-independent cell cycle regulation by nucleolar proteins 7: Nucleolar stress and DNA repair 8: The role of NPM1 in protecting from genomic instability 9: The nucleolus and cell death pathways 10: Nucleolar proteins in cancer 11: Conclusions References Chapter Eight: Chromatin regulators in DNA replication and genome stability maintenance during S-phase Abstract 1: Replication of chromatin 2: Cellular response to replication stress 3: Chromatin factors involved in DNA replication initiation 4: Chromatin in the maintenance of DNA replication elongation and replication stress protection 5: Chromatin events at stalled forks 6: Transcription-induced replication stress 7: Exploiting replication stress 8: Concluding remarks Acknowledgments References Chapter Nine: Role of macrophages in cancer progression and targeted immunotherapies Abstract 1: Overview of tumor-associated macrophages 2: Polarization of TAMs 3: TAMs involvement in tumor progression 4: Role of TAMs in immune response 5: Cell cycle regulation in TAMs and cancer cells 6: Therapies targeting cancer cell cycle progression by targeting TAMs 7: Future directions References Chapter Ten: Therapeutic targets in cancer treatment: Cell cycle proteins Abstract 1: Introduction 2: Tumor cell cycle phase analysis 3: Cell-cycle checkpoint 4: Targeting cell cycle kinases in cancer therapy 5: Role of D-type cyclins in cancer 6: Role of cyclin E in cancer 7: Role of cyclin B and CDK1 in cancer 8: Role of polo-like kinases (Plks) family members in cancer 9: Plks in cancer development 10: DNA damage checkpoint kinases 11: Currently used cyclin inhibitors 12: Concluding remarks References Chapter Eleven: Anti-cancer drug molecules targeting cancer cell cycle and proliferation Abstract 1: Introduction 2: Overview of cell cycle checkpoints 3: Disturbance in cancer cell cycle checkpoints 4: Anti-cancer drugs 5: Drugs that target cell cycle proteins 6: Cancer cell proliferation inhibitors 7: Conclusion References Chapter Twelve: Cellular signals integrate cell cycle and metabolic control in cancer Abstract 1: Growth factors in cancer 2: Growth factor signal transduction and biological responses 3: Growth factor-dependent signaling and cell cycle progression 4: The cell cycle controls the metabolism 5: Conclusion References Chapter Thirteen: Therapeutic targeting and HSC proliferation by small molecules and biologicals Abstract 1: Introduction 2: Cell cycle kinetics of hematopoietic stem cells 3: Hematopoietic stem cells expansion technologies 4: Small molecule-induced HSC expansion 5: Clinical perspective on HSC expansion 6: Conclusion References Chapter Fourteen: Mechanism of cell cycle regulation and cell proliferation during human viral infection Abstract 1: Introduction 2: Cell cycle: An overview 3: Brief account of viruses involved in the regulation of the cell cycle 4: Mechanistic account of virus mediated cell regulation 5: Conclusions References