ISBN : 9780443191435
Author : Siddhartha Pati
Publisher : Elsevier
Year : 2023
Language : English
Type : Book
Description : Table of contents Cover image Title page Table of Contents Copyright Dedication List of contributors Preface Acknowledgment Chapter 1. Extraction, isolation, and characterization of phytochemicals, the bioactive compounds of plants Abstract 1.1 Introduction 1.2 Extraction of phytochemicals 1.3 Isolation and purification of phytoconstituents 1.4 Identification of phytochemicals 1.5 Conclusion Acknowledgments References Chapter 2. Importance and extraction techniques of functional components Abstract 2.1 Introduction 2.2 Current techniques for extraction of phytochemicals 2.3 Characterization of phytochemicals 2.4 Conclusion 2.5 Future considerations for effective extraction of phytochemicals References Chapter 3. Novel extraction conditions for phytochemicals Abstract 3.1 Introduction 3.2 Pre-extraction conditions 3.3 Selecting a pre-extracting sample preparation 3.4 Extraction conditions 3.5 Selection approach for a suitable extraction method 3.6 Conclusion References Chapter 4. Novel extraction and characterization methods for phytochemicals Abstract 4.1 Introduction 4.2 Extraction methods 4.3 Separation techniques 4.4 Applications of chromatography techniques 4.5 Characterization methods 4.6 Conclusions and future directions References Chapter 5. Phytochemicals: recent trends in food, pharmacy, and biotechnology Abstract 5.1 Introduction 5.2 Bioactive phytochemicals 5.3 Antioxidant and antimicrobial properties of phytochemicals 5.4 Phytochemicals from the agri-food by-products 5.5 Pharmacological aspects of phytochemicals 5.6 Nanodrug delivery of the phytochemicals in treating cancer 5.7 Current limitations and future of phytochemicals 5.8 Conclusion and future prospect References Chapter 6. Phytochemicals as bioactive ingredients for functional foods Abstract 6.1 Introduction 6.2 Phytonutrients 6.3 Health-promoting ability of phytochemicals 6.4 Biological activities of phytochemicals 6.5 Phytochemicals-based functional foods 6.6 Future perspective 6.7 Conclusion References Chapter 7. Exploring the role of Mahua as a functional food and its future perspectives Abstract 7.1 Introduction 7.2 Traditional uses 7.3 Nutritional and phytochemical profiling 7.4 Pharmaceutical uses and pharmacological importance 7.5 Mahua as a functional food 7.6 Current trends and future perspectives Acknowledgment References Chapter 8. Functional beverages: an emerging trend in beverage world Abstract 8.1 Introduction 8.2 Market of nutraceutical or functional beverages 8.3 Soft drinks 8.4 Nonalcoholic beverages 8.5 Probiotics beverages 8.6 Fruits-based beverages 8.7 Fermented beverages 8.8 Whey-based beverages 8.9 Micronutrient-fortified beverage 8.10 Beverages rich in antioxidants and herbs 8.11 Prebiotic beverages 8.12 Sports or energy drinks 8.13 Storage study of beverages 8.14 Health safety of drinks 8.15 Consumer demand for beverages References Chapter 9. Recent targeted discovery of phytomedicines to manage endocrine disorder develops due to adapting sedentary lifestyle Abstract 9.1 Introduction 9.2 Concept of herbal targeted drug delivery 9.3 List of most effective phytochemicals/phytomedicinal herbs 9.4 List of novel phytomedicinal formulations in pharmacy to target the endocrine glands and hormone for the treatment of various major endocrine disorders 9.5 Application of phytomedicine in modern drug development in pharmacy 9.6 Advantages of herbal phytomedicines in modern system 9.7 Conclusion References Chapter 10. Current updates on phytopharmaceuticals for cancer treatment Abstract 10.1 Introduction 10.2 Phytochemicals unexplored 10.3 Molecular mechanism of phytochemicals in preventing cancer 10.4 Strategies to improve phytochemical drugability 10.5 Drug delivery approach to improve phytochemical drugability 10.6 Phytochemicals in clinical and preclinical stages for preventing cancer 10.7 Insights on phytochemicals as dietary recommendation in cancer 10.8 Conclusion and future perspectives References Chapter 11. Phytochemicals in prostate cancer Abstract 11.1 Introduction 11.2 Types of prostate cancer 11.3 Causes of prostate cancer 11.4 Symptoms of prostate cancer 11.5 Test to identify prostate cancer 11.6 Prostate cancer treatments 11.7 Prevention of prostate cancer 11.8 Phytochemicals in prostate cancer 11.9 Phytochemicals and conventional medical practice 11.10 Effects of specific plant families extracts on human prostate cancer cells 11.11 Prostate cancer risk factors 11.12 Conclusion References Further reading Chapter 12. Therapeutic phytochemicals from Plumbago auriculata: a drug discovery paradigm Abstract 12.1 Introduction 12.2 Traditional uses 12.3 Phytochemistry 12.4 Plumbagin 12.5 Medicinal uses 12.6 Nano-biotechnology 12.7 Other properties 12.8 Future perspectives 12.9 Conclusion Acknowledgments References Chapter 13. Alkaloids as potential anticancer agent Abstract 13.1 Introduction 13.2 Theoretical relevance 13.3 Biological source, mechanism of action, and applications of indole alkaloids 13.4 Biological source, mechanism of action, and applications of isoquinoline alkaloids 13.5 Biological source, mechanism of action, and applications of Taxus alkaloid 13.6 Aporphinoid alkaloids 13.7 Emetine and related alkaloids 13.8 Biological source, mechanism of action, and applications of Cephalotaxus alkaloids 13.9 Biological source, mechanism of action, and applications of pyrrolizidine alkaloids 13.10 Anticancer alkaloids with future perspective References Chapter 14. Potential phytochemicals as microtubule-disrupting agents in cancer prevention Abstract 14.1 Introduction 14.2 Molecular basis of microtubule dynamics 14.3 Factors affecting microtubule dynamics in cancer cells 14.4 Intracellular stress in cancer 14.5 Targeting microtubules in cancer 14.6 Alkaloids as microtubulin-disrupting agents 14.7 Taxol as a therapeutic agent disrupting cell polymerization 14.8 Colchicine as a microtubule-disrupting agent 14.9 Curcumin, a phenolic compound, disrupts microtubule function 14.10 Noscapine therapeutic agents disrupting microtubule dynamics 14.11 Coumarin’s background and therapeutic activities 14.12 Discussion 14.13 Conclusion Acknowledgment References Chapter 15. Therapeutic effectiveness of phytochemicals targeting specific cancer cells: a review of the evidence Abstract 15.1 Introduction 15.2 Strategies for identification of phytochemicals with pharmaceutical potential 15.3 Perceptions of phytochemicals as anticancer agents in the history 15.4 Synthetic analogs for plant-derived compounds: enhancement and application 15.5 Classification of phytochemicals 15.6 Plant-derived phytochemicals currently in use for various cancer treatments 15.7 Curcumin 15.8 Quercetin 15.9 Vinca alkaloids 15.10 Camptothecin 15.11 Cervical cancer and phytochemicals 15.12 Current scenario and future perspective Competing interests References Chapter 16. Understanding the role of the natural warriors: phytochemicals in breast cancer chemoprevention Abstract 16.1 Introduction 16.2 Breast cancer: definition, subtypes, and conventional therapies 16.3 Perils of conventional BC therapies 16.4 Role of complementary and alternative medicine (CAM) in breast cancer treatment 16.5 Phytochemicals: traversing a new window in breast cancer therapy 16.6 Phytochemicals and ER(+) breast cancer 16.7 Phytochemicals and HER(2) breast cancer 16.8 Phytochemicals used for triple-negative breast cancer (TNBC) 16.9 Role of phytochemicals in modulating noncoding RNA expression in BC cells 16.10 Phytochemical interventions in healing cancer-associated MDR 16.11 Diet and dietary phytochemicals in chemosensitization 16.12 Challenges and perspectives: into the future of BC phytochemical interventions 16.13 Conclusion References Chapter 17. Phytochemicals and cancer Abstract 17.1 Introduction 17.2 Role of phytochemicals in various diseases 17.3 Phytochemicals in cancer References Chapter 18. Phytochemicals as a complementary alternative medicine in cancer treatment Abstract 18.1 Introduction 18.2 Role of oxidative stress in carcinogenesis 18.3 Mode of action of phytochemicals for cancer prevention by targeting cellular signaling transduction pathways 18.4 A historical perspective of plant-derived drugs used popularly in cancer 18.5 Phytochemicals induce cancer cell apoptosis and autophagy 18.6 Gut microbiota in gastrointestinal malignancy—a potential target for phytotherapy 18.7 Plant-derived drugs 18.8 Conclusion 18.9 Challenges References Chapter 19. Applications of phytochemicals in cancer therapy and anticancer drug development Abstract 19.1 Introduction 19.2 Conclusion References Chapter 20. Bioactivity, medicinal applications, and chemical compositions of essential oils: detailed perspectives Abstract 20.1 Introduction 20.2 Chemistry of essential oils 20.3 Biological activity of essential oils 20.4 Medicinal applications of essential oils 20.5 Conclusion References Chapter 21. Biological potential of essential oils in pharmaceutical industries Abstract 21.1 Introduction 21.2 Bioactive components of essential oils 21.3 Biological activities of EO 21.4 Cancer-preventing function 21.5 Antioxidant and anti-inflammatory properties 21.6 Role in cardiovascular diseases 21.7 Antidiabetic agents 21.8 Other important properties 21.9 Application of EO in pharmaceutical industry 21.10 Future perspective and conclusion References Chapter 22. A review on marine-based phytochemicals and their application in biomedical research Abstract 22.1 Introduction 22.2 Phytochemicals from marine resources 22.3 Metabolic process to form marine phytochemicals 22.4 Bioactive potential of marine phytochemical 22.5 Biomedical applications of marine phytochemicals 22.6 Conclusion References Chapter 23. Phytochemicals in biofilm inhibition Abstract 23.1 Introduction 23.2 Biofilm formation 23.3 Inactivation mechanism of biofilm 23.4 Role of phytochemicals in biofilm inhibition 23.5 Phenolics 23.6 Terpenoids 23.7 Organic acids 23.8 Other phytochemicals 23.9 Sulfur- and nitrogen-containing phytochemicals 23.10 Future perspective and conclusion References Chapter 24. New perspectives and role of phytochemicals in biofilm inhibition Abstract 24.1 Introduction 24.2 Biofilm development and its health hazards 24.3 Occurrence of biofilms 24.4 Phytochemicals in biofilm inhibition 24.5 Conclusion References Chapter 25. Novel perspectives on phytochemicals-based approaches for mitigation of biofilms in ESKAPE pathogens: recent trends and future avenues Abstract 25.1 Introduction 25.2 Biofilm-mediated drug resistance in ESKAPE pathogens 25.3 Mitigation of biofilm architecture: current therapeutic trends 25.4 Phytochemicals-based mitigation strategies against biofilm formation 25.5 Current trends in biofilm inhibition 25.6 Future perspectives Key points Acknowledgment References Chapter 26. Phytochemicals in downregulation of quorum sensing Abstract 26.1 Introduction 26.2 Biofilm formation and quorum sensing 26.3 Mechanism of quorum sensing in bacteria 26.4 Phytochemicals as quorum-sensing inhibitors 26.5 Clinical studies 26.6 Mechanism of phytochemicals involved in quorum-sensing inhibition 26.7 Conclusion Acknowledgment References Chapter 27. Phytoconstituents-based nanoformulations for neurodegenerative disorders Abstract 27.1 Introduction 27.2 Key issues associated with neurodegenerative diseases 27.3 Significance of nanotechnology in neurodegenerative disorders: incapacitating the blood–brain barrier 27.4 Phytoconstituents and their general mechanism of actions pertaining to neuroprotection 27.5 Phyto-nanomedicine in the management of neurodegenerative disorders 27.6 Nanoformulations in tackling neurodegeneration: preclinical proofs 27.7 Limitations of nanotechnology-based approaches for management of neurodegenerative disorders 27.8 Future outlook and conclusion References Chapter 28. Oxidative stress and its management through phytoconstituents Abstract 28.1 Introduction 28.2 Oxidative stress and free radicals 28.3 Antioxidants 28.4 Antioxidative effect of phytoconstituents 28.5 Conclusion References Chapter 29. Phytochemicals: an immune booster against the pathogens Abstract 29.1 Introduction 29.2 Secondary metabolites 29.3 Phytotherapy 29.4 Phytomedicine 29.5 SARS-CoV-2 References Chapter 30. Phytochemicals: recent trends and future prospective in COVID-19 Abstract 30.1 Introduction 30.2 Virus-based targets 30.3 Host-based targets 30.4 Conclusion and future prospective References Chapter 31. Phytochemicals—a safe fortification agent in the fermented food industry Abstract 31.1 Introduction 31.2 Types of phytochemicals 31.3 Health benefits of phytochemicals 31.4 Fortification in the fermentation industry 31.5 Effect of fermentation on phytochemicals 31.6 Use of phytochemicals as a safe fortifying agent 31.7 Limitations 31.8 Conclusion References Chapter 32. Molecular docking study of bioactive phytochemicals against infectious diseases Abstract 32.1 Introduction 32.2 Molecular docking studies of plant products as anti-coronal agents 32.3 Molecular docking studies of plant products as anti-leishmanial agents 32.4 Molecular docking studies of plant products as antitubercular agents 32.5 Conclusion References Chapter 33. Phytochemicals in structure-based drug discovery Abstract 33.1 Introduction 33.2 Phytochemicals screening of plant extracts 33.3 Phytochemicals from Phytolacca dioica L. seeds extracts—case study I 33.4 Phytochemicals composition and biological properties of seed extracts from Washingtonia filifera—case study II 33.5 Phytochemicals—opportunities and challenges References Chapter 34. Modulation of drug resistance in leukemia using phytochemicals: an in-silico, in-vitro, and in-vivo approach Abstract 34.1 Introduction 34.2 Drug resistance: therapeutic failure in leukemia 34.3 Combination index method and synergism 34.4 Phytochemicals as chemosensitizer and modulators 34.5 Conclusions and future prospects Acknowledgment References Chapter 35. Phytochemical and bioactive potentialities of Melastoma malabathricum Abstract 35.1 Introduction 35.2 Ethno-medicinal practices 35.3 Phytochemical constituents 35.4 Pharmacological potentialities 35.5 Conclusion and future perspective References Chapter 36. Bioactivity of essential oils and its medicinal applications Abstract 36.1 Introduction 36.2 Chemical structure of flavonoids 36.3 Flavonoids activity against multidrug-resistant microbes 36.4 Conclusion Ethics declarations References Chapter 37. Essential oils as anticancer agents Abstract 37.1 Introduction 37.2 Anticancer potential of essential oils 37.3 Conclusion and future perspective Abbreviations References Chapter 38. Molecular docking study of bioactive phytochemicals against cancer Abstract 38.1 Introduction 38.2 Molecular docking of bioactive phytochemicals with anticancer properties 38.3 Conclusion References Index