ISBN : 9780323958844
Author : Dhanjoo N. Ghista
Publisher : Academic Press
Year : 2023
Language : English
Type : Book
Description : Table of contents Cover Image Title Page Copyright Table of Contents Contributors Author Preface Acknowledgments Introduction Section I Pancreatic and Glucose-Insulin Regulatory System Engineering and Medical Assessment Chapter 1 Pancreatic Regulatory Physiology and Medical Assessment Chapter Outline Abstract 1.1 Pancreatic regulatory physiology 1.2 Medical assessment of pancreatic function 1.3 Oral glucose tolerance test mathematical modeling to detect diabetic subjects References Chapter 2 Glucose-Insulin Regulatory Kinetics Chapter Outline Abstract 2.1 Background and motivation for this project 2.2 Literature review 2.3 Our work: the oral glucose tolerance testing protocol: adopted for classification of subjects to be normal or diabetic 2.4 Our work on systems engineering analysis of OGTT blood glucose and insulin response 2.5 Clinical applications of the model 2.6 Combined nondimensional physiological index (DNDI) representing both glucose and insulin model responses 2.7 Conclusion Appendix A: Solution of Equation (2.20), as given by Equations (2.21), (2.22) and (2.23) Appendix B: Solution of Equation (2.24), as given by Equation (2.25) Appendix C: Solution of Equation (2.26), as given by Equation (2.27) Appendix D: Solution of Equation (2.28), as given by Equation (2.29) Appendix E: Results of our works on classifications of subjects versus diagnosis by clinicians References Chapter 3 Automated Insulin Infusion Regulatory System Chapter Outline Abstract 3.1 Motivation behind the project 3.2 Functions of the pancreas 3.3 Literature review (glucose measurement) 3.4 Overview of current diabetes treatment and monitoring methods 3.5 Noninvasive insulin delivery system 3.6 Our work on the Automated Artificial Pancreas system 3.7 Control system for Insulin Infusion 3.8 Our work on Controller Type Selection 3.9 Derivation of Insulin Response in the Blood Pool 3.10 Simulated results of the Insulin Infusion System and its Blood Glucose Response 3.11 Conclusion Appendix A Appendix B References Chapter 4 Using Diabetes Technology to Maximize Diabetes Management Chapter Outline Abstract 4.1 Introduction 4.2 Continuous glucose monitoring systems 4.3 Smart insulin pens 4.4 What is a smart insulin pen? 4.5 Insulin pumps 4.6 Diabetes digital data management and support 4.7 Clinical case: a patient using diabetes technology to maximize diabetes management 4.8 Discussion: the take-home messages 4.9 Conclusion: the overall impression References Section II Respiratory and Pulmonary System Engineering and Medical Assessment Chapter 5 Physiologic and Medical Assessments of Respiratory Mechanics and Ventilation Chapter Outline Abstract Nomenclature 5.1 Introduction 5.2 Inverse modeling of respiratory mechanics 5.3 Forward modeling of respiratory mechanics 5.4 Conclusion References Chapter 6 Lung Ventilation Modeling and Medical Assessment Chapter Outline Abstract 6.1 Motivation behind the project 6.2 Pulmonary system 6.3 Literature review 6.4 Work of breathing 6.5 Model of diseased lung 6.6 Ventilation distribution model with nonlinear components 6.7 Our lung ventilation model 6.8 Ventilatory index 6.9 Variations in R and C during a respiratory cycle (towards nonlinear formats of C and R) 6.10 Work of breathing (WOB) 6.11 For noninvasive assessment of lung status, and determination of lung compliance and resistance-to-airflow 6.12 Two-compartmental first-order ventilatory model 6.13 Conclusion Appendix A Appendix B References Chapter 7 Respiratory Control Mechanism-Modeling Chapter Outline Abstract 7.1 Objectives 7.2 Introduction 7.3 Principal components of the respiratory process control system 7.4 Respiratory process control model: important variables employed 7.5 MATLAB-Simulink model 7.6 Case study: coronavirus effects in respiratory system 7.7 Summary References Chapter 8 Lung Alveoli and Pulmonary Capillary Gas Transfer Analysis Chapter Outline Abstract 8.1 Objectives 8.2 Respiratory system 8.3 Lung air composition analysis (and O2 consumption and CO2 production rates) 8.4 Lung gas-exchange model and parametric analysis 8.5 Sequential procedure to compute the diffusion coefficients DO2 and DCO2 8.6 Case studies to demonstrate evaluation of the diffusion coefficients 8.7 Nondimensional gas-transfer index (NDGTI) 8.8 Conclusion References Section III Renal System Engineering and Medical Assessment Chapter 9 Renal Physiology Theory and Functional Assessment Chapter Outline Learning objectives Abstract 9.1 Introduction 9.2 Functions of the kidney 9.3 Physiological anatomy of the kidneys 9.4 Mechanism of urine formation 9.5 Electrolyte balance 9.6 Acid base balance 9.7 Role of the kidneys in formation of EPO 9.8 Blood pressure regulation 9.9 Endocrine regulation of kidney function 9.10 Kidney function tests 9.11 Chronic kidney disease overview 9.12 Acute kidney injury (AKI) overview Bibliography Chapter 10 Determining Kidney Obstructions by Renogram Data Modeling Chapter Outline Abstract 10.1 Radionuclide renal scan for split renal function 10.2 Evaluation of renal function by radionuclide methods 10.3 Diagnostic methods 10.4 Clinical applications 10.5 Renography 10.6 Scintigraphic procedure 10.7 Processing and analysis of the study 10.8 Literature review on measurement of glomerular filtration rates 10.9 Renography modeling References Chapter 11 Artificial Kidney Function and Dialysis Physiology: Mechanisms and Analysis of Hemodialysis and Peritoneal Dialysis Chapter Outline Abstract Learning Objectives 11.1 Introduction 11.2 Artificial kidney function, by dialysis machine and dialyser filter 11.3 Hemodialysis 11.4 Example of an appropriate dialysis prescription for a chronic maintenance dialysis patient 11.5 Peritoneal dialysis Bibliography Chapter 12 Renal Physiology Modeling, Part 1: Acid Base Balance, Part 2: Body Fluid Balance Chapter Outline Abstract 12.1 Objectives 12.2 Introduction 12.3 Regulatory biological/physiological control system 12.4 Kidney, the actuator 12.5 Renal physiology modeling part 1: acid–base balance 12.6 Renal physiology modeling part 2: body fluid balance 12.7 Summary of the chapter References Index